The many new opportunities that are opened up by Industrie 4.0 also bring a host of different challenges. ‘Security by design’, for example, becomes an indispensable element in design within Industrie 4.0. Security acts as a skeleton that carries and holds together all of the structural elements within RAMI4.0 and, as a result, the design of the Industrie 4.0 component. The guideline seeks to provide the reader with a clear overview of the various security aspects within RAMI4.0. Various security measures are explored using a range of examples that are built upon on all three of the RAMI4.0 axes.