Companies should focus on exploiting the stability afforded by their core business, while at the same time exploring innovations and experimentation for digital transformation. Ambidexterity requires a new „digital way of doing things“ in an organization’s people, processes and structure. Achieving an organizational culture of ambidexterity is a fundamental accelerator for organizations to pivot to Industrie 4.0, drive quantifiable change, implement agility and achieve long-term business objectives and outcomes at the intersection of human and machine.